Profile Project

Information updated to: 31/08/2016

Project

Nuove strategie nanotecnologiche per la messa a punto di farmaci e presidi diagnostici diretti verso cellule cancerose circolanti

Code PON01_02782
Field/s Health and wellbeing
Description Circulating tumor cells (CTCs) are emerging as a powerful prognostic and predictive biomarker in several types of cancer, including breast, colon, and prostate. However, studies of CTCs in metastasis and further development of CTCs as a biomarker in cancer have been hampered by the low concentration of CTCs in peripheral blood and by the inherent difficulties to recover CTCs from blood of patients. For this reason, it is compelling to implement novel devices and procedures to improve isolation rate and in vitro expansion of CTCs. We propose to develop a nanostructured device that combines analytic and preparative properties to improve speed and efficency of isolation of CTCs from blood of patients affected by carcinomas and/or multiple myeloma, to develop protocols for the ex-vivo expansion of these cells, and to complete a molecular characterization to clearly define the mutational, transcriptional and proteomic profiles of CTCs. This will lead to the development of basic diagnostic kits that will be of help in the diagnosis of cancer and/or to the discovery of novel markers of pharmaceutical resistance as well as the identification of new targeted agents for treatment of cancer. A second objective of the project consists of development of innovative technologies that combine the generation of conjugated Ab-siRNA and the implementation of nanoparticles that augment the efficiency of delivery of drugs and biological molecules, to efficiently target CTCs. The third objective of the project is the identification of small molecules and/or peptides with anti-tumoral activity to CTCs.
Total cost 8,640,617.06 euro
Public contribution
Total public contribution
7,122,149.51 euro

NOP R&C contribution
6,586,449.51 euro

PAC contribution
0.00 euro

Contribution from other funds
535,700.00 euro
Distribution Advancement of distribution in %
Total amount distributed
5,023,320.51 euro

NOP R&C distributed amount
4,862,610.51 euro

PAC distributed amount
0.00 euro

Amount distributed with other funds
160,710.00 euro

Legend

Field/s – Indicates the field or fields in which the project has the most relevance. A project may have more than one field. For some projects it is not assigned. The field are the following 8: "Health and wellbeing", "Food", "Energy", "Environment and Ecology", "Transport and Logistics", "Cultural goods and activities", "Social Innovation" and "Smart Cities".

Description – Descriptive summary of project.

Total cost – Total cost of project.

Public contribution – Three elements are reported:

  • Total commitment – total amount admitted to financing, may include more than contribution to be valued on NOP R&C, also on other funds.
  • NOP R&C admitted contribution
  • PAC admitted contribution
  • Contribution with other funds

Distribution – The following elements are reported:

  • Total distributed amount – takes into account the distributed amount considering both NOP R&C distribution and other funds if provided for
  • NOP R&C distributed amount – amount distributed to financing of project to be valued on NOP R&C
  • PAC distributed amount – amount distributed to financing of project to be valued on PAC
  • Amount distributed with other funds – amount distributed to financing of project with other funds

The distributions refer to the date of last update indicated at top.

Type of beneficiary Public commitment for beneficiary
Public research organisation 2
Research Organisation 4
University 3
Small business 2
Total Beneficiaries 11

Stazione Zoologica Anthon Dohrn

Tax File Number: 04894530635
Unique Project Code: C61H11000030005
Location of financial commitments: Campania
Type: Public research organisation
See beneficiary profile >
Presentation date 09/04/2010
Approval date 22/12/2015
Start of activity Expected date
01/09/2011 		Effective date
01/09/2011
End of activity Expected date
30/10/2015 		Effective date
-
Total cost 694,750.00 euro
Public contribution Total
590,537.50 euro 		Eligible of NOP R&C
590,537.50 euro
Distribution Total
590,537.50 euro 		Amount of NOP R&C
590,537.50 euro

Date of last distribution of NOP R&C
-

BIOGEM S.C.a r.l.

Tax File Number: 02071230649
Unique Project Code: B81H11001130005
Location of financial commitments: Campania
Type: Research Organisation
See beneficiary profile >
Presentation date 09/04/2010
Approval date 22/12/2015
Start of activity Expected date
01/09/2011 		Effective date
01/09/2011
End of activity Expected date
30/10/2015 		Effective date
-
Total cost 1,427,767.06 euro
Public contribution Total
1,213,602.00 euro 		Eligible of NOP R&C
1,213,602.00 euro
Distribution Total
908,990.00 euro 		Amount of NOP R&C
908,990.00 euro

Date of last distribution of NOP R&C
-

Fondazione Istituto Italiano di Tecnologia

Tax File Number: 97329350587
Unique Project Code: B71H11000870005
Location of financial commitments: Puglia
Type: Research Organisation
See beneficiary profile >
Presentation date 09/04/2010
Approval date 22/12/2015
Start of activity Expected date
01/09/2011 		Effective date
01/09/2011
End of activity Expected date
30/10/2015 		Effective date
-
Total cost 505,100.00 euro
Public contribution Total
429,335.00 euro 		Eligible of NOP R&C
429,335.00 euro
Distribution Total
429,335.00 euro 		Amount of NOP R&C
429,335.00 euro

Date of last distribution of NOP R&C
-

CEINGE Biotecnologie Avanzate SCARL

Tax File Number: 04378020632
Unique Project Code: B61H11001280005
Location of financial commitments: Campania
Type: Research Organisation
See beneficiary profile >
Presentation date 09/04/2010
Approval date 22/12/2015
Start of activity Expected date
01/09/2011 		Effective date
01/09/2011
End of activity Expected date
30/10/2015 		Effective date
-
Total cost 609,000.00 euro
Public contribution Total
517,650.00 euro 		Eligible of NOP R&C
517,650.00 euro
Distribution Total
517,650.00 euro 		Amount of NOP R&C
517,650.00 euro

Date of last distribution of NOP R&C
-

Università degli Studi Magna Grecia di Catanzaro

Tax File Number: 97026980793
Unique Project Code: B61H11001270005
Location of financial commitments: Calabria
Type: University
See beneficiary profile >
Presentation date 09/04/2010
Approval date 22/12/2015
Start of activity Expected date
01/09/2011 		Effective date
01/09/2011
End of activity Expected date
30/10/2015 		Effective date
-
Total cost 258,500.00 euro
Public contribution Total
219,725.00 euro 		Eligible of NOP R&C
219,725.00 euro
Distribution Total
172,125.00 euro 		Amount of NOP R&C
172,125.00 euro

Date of last distribution of NOP R&C
-

ISTITUTO SUPERIORE DI ONCOLOGIA-ISO

Tax File Number: 95024300105
Unique Project Code: B61H11001260005
Location of financial commitments: Non disponibile
Type: Research Organisation
See beneficiary profile >
Presentation date 09/04/2010
Approval date 22/12/2015
Start of activity Expected date
01/09/2011 		Effective date
01/09/2011
End of activity Expected date
30/10/2015 		Effective date
-
Total cost 275,000.00 euro
Public contribution Total
233,750.01 euro 		Eligible of NOP R&C
233,750.01 euro
Distribution Total
233,750.00 euro 		Amount of NOP R&C
233,750.00 euro

Date of last distribution of NOP R&C
-

UNIVERSITÀ DEGLI STUDI DI NAPOLI FEDERICO II

Tax File Number: 00876220633
Unique Project Code: B61H11001250005
Location of financial commitments: Campania
Type: University
See beneficiary profile >
Presentation date 09/04/2010
Approval date 22/12/2015
Start of activity Expected date
01/09/2011 		Effective date
01/09/2011
End of activity Expected date
30/10/2015 		Effective date
-
Total cost 395,000.00 euro
Public contribution Total
335,750.00 euro 		Eligible of NOP R&C
335,750.00 euro
Distribution Total
335,750.00 euro 		Amount of NOP R&C
335,750.00 euro

Date of last distribution of NOP R&C
-

CNR - Consiglio nazionale delle ricerche

Tax File Number: 80054330586
Unique Project Code: B51H11000850005
Location of financial commitments: Campania
Type: Public research organisation
See beneficiary profile >
Presentation date 09/04/2010
Approval date 22/12/2015
Start of activity Expected date
01/09/2011 		Effective date
01/09/2011
End of activity Expected date
30/10/2015 		Effective date
-
Total cost 1,118,800.00 euro
Public contribution Total
950,980.00 euro 		Eligible of NOP R&C
950,980.00 euro
Distribution Total
950,980.00 euro 		Amount of NOP R&C
950,980.00 euro

Date of last distribution of NOP R&C
-

Università degli Studi di Milano-Bicocca

Tax File Number: 12621570154
Unique Project Code: B41H11000720005
Location of financial commitments: Campania, Extra convergenza
Type: University
See beneficiary profile >
Presentation date 09/04/2010
Approval date 22/12/2015
Start of activity Expected date
01/09/2011 		Effective date
01/09/2011
End of activity Expected date
30/10/2015 		Effective date
-
Total cost 514,000.00 euro
Public contribution Total
436,900.00 euro 		Eligible of NOP R&C
350,200.00 euro
Distribution Total
376,210.00 euro 		Amount of NOP R&C
350,200.00 euro

Date of last distribution of NOP R&C
-

ITALSISTEMI S.r.l.

Tax File Number: 01948610793
Unique Project Code: B11H11000520005
Location of financial commitments: Calabria
Type: Small business
See beneficiary profile >
Presentation date 09/04/2010
Approval date 22/12/2015
Start of activity Expected date
01/09/2011 		Effective date
01/09/2011
End of activity Expected date
30/10/2015 		Effective date
-
Total cost 1,704,000.00 euro
Public contribution Total
1,318,600.00 euro 		Eligible of NOP R&C
1,318,600.00 euro
Distribution Total
74,869.01 euro 		Amount of NOP R&C
74,869.01 euro

Date of last distribution of NOP R&C
-

Areta International

Tax File Number: 12914940155
Unique Project Code: B11H11000510005
Location of financial commitments: Campania, Extra convergenza
Type: Small business
See beneficiary profile >
Presentation date 09/04/2010
Approval date 22/12/2015
Start of activity Expected date
01/09/2011 		Effective date
01/09/2011
End of activity Expected date
30/10/2015 		Effective date
-
Total cost 1,138,700.00 euro
Public contribution Total
875,320.00 euro 		Eligible of NOP R&C
426,320.00 euro
Distribution Total
433,124.00 euro 		Amount of NOP R&C
298,424.00 euro

Date of last distribution of NOP R&C
-
Axis - Operational objective I - Scientific and technological fields, generators of industry transformation processes and creators of new sectors (Go to )
Action Strategic scientific and technological areas
Action line Industrial Research (Go to)
Instrument of implementation Invitation to presentation of Industrial Research projects (DD 1/Ric 18/01/10)
NSF - objective Strengthen and evaluate the whole chain of research and cooperation networks between the research system and businesses, to contribute to competitiveness and economic growth; sustain maximum distribution and use of new technologies and advanced services; heighten level of scientific and technical knowledge and skills in the production system and in institutions
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