Profile Project

Information updated to: 31/08/2016

Project

Ricerca e Sviluppo di bioregolatori attivi sui meccanismi epigenetici dei processi infiammatori nelle malattie croniche e degenerative (Acronimo: BIAM-EPI)

Code PON01_02512
Field/s Health and wellbeing
Description The BIAM-EPI project arises from specific knowledge available to the project proposal group and the will to integrate the existing excellent research cooperation, looking to an optimal and further productive fall-out of Science and Technology in areas impacting on health and quality of life, to be allocated in 2 areas of the Italian Regional Convergence. The partners of the present project proposal intend to create a Temporary Association of Purpose to guarantee a shared approach to the present proposal objectives. Epitech Group has been identified as the leader partner of the project in consideration of the innovative industrial know-how belonging to this company. As per training and education, a fundamental tool of improvement for skills and education in the referred areas, it has been identified a consortium with academic skills staff, to be in charge for this role in line with the project purpose. On the research side, BIAM-EPI plans to develop active raw materials functioning as bioregulators on chronic inflammatory processes or on low-grade inflammation and neuroinflammation. Bioregulators will be developed starting from Aliamides also associated with Polyphenols belonging to Stilbenes and/or Flavons family. Aliamides, endogenous lipidic molecules, are capable to down-regulate genetic transcription factors. Stilbenes and Flavons are molecules naturally present in food; Stilbenes are specifically active on sirtuins during restoration of functional regulation of gene expression. 4 work-packages (WP) contribute to achieve the BIAM-EPI goals. WP1 goal is the design, realization and development of molecules and adducts between active raw materials and a carrier, suitable to be used as bioregulators. Both classes of molecules subject of the study are scarcely hydrophilic, so actions under WP1 will be carried out using advanced technologies for bioavailability optimization, biocompatibility and pharmacokinetic. WP2 is focused on evaluating and characterising effects of bioregulators in experimental models in vitro and in vivo, reproducing same conditions of chronic inflammation or low grade inflammation, in peripheral districts. Activities performed under WP2 will bring to identify bioregulators active on different studied districts, mechanism of action and, to highlight the relation between inflammatory activity and genetic transcription regulation. WP2 actions, notably the use of different experimental models in vivo, some of which are characterized by a low grade inflammation, will allow exploring bioregulators effects also on neuropathic pain, on electroneurographic alterations and on small nervous fibres density. WP3 aims at identify and characterize, with adequate experimental models in vitro and in vivo, bioregulators active on processes of neuroinflammation and neurodegeneration in CNS in experimental models of Cerebral Ischemia, Parkinson’s or Alzheimer’s diseases or Multiple Sclerosis. WP4 aims at studying the application of bioregulators to man through acquisition of specific knowledge on epigenetic alterations in diseases characterized by chronic inflammation and their relation with inflammation marker, clinical symptomatology and functional electroneurographic alterations. The final goal of BIAM-EPI is getting bioregulators made of active molecules, or association of active molecules, or adduct of active molecules and carriers, having suitable formulations for different analyzed districts, to be bioavailable and well tolerated by the organism, letting innovative therapeutic interventions targeted to counteract chronic inflammation, low-grade inflammation or neuroinflammation deemed as risk factors for the development of several chronic and degenerative diseases. It is fundamental consolidating and strengthen the existing network organization involving different expertises of absolute excellence in a synergic joint work between Partners and Third Subjects, also contributing to further education and employment.
Total cost 12,750,517.54 euro
Public contribution
Total public contribution
9,973,008.69 euro

NOP R&C contribution
9,392,608.74 euro

PAC contribution
0.00 euro

Contribution from other funds
580,399.95 euro
Distribution Advancement of distribution in %
Total amount distributed
7,267,476.92 euro

NOP R&C distributed amount
7,267,476.92 euro

PAC distributed amount
0.00 euro

Amount distributed with other funds
0.00 euro

Legend

Field/s – Indicates the field or fields in which the project has the most relevance. A project may have more than one field. For some projects it is not assigned. The field are the following 8: "Health and wellbeing", "Food", "Energy", "Environment and Ecology", "Transport and Logistics", "Cultural goods and activities", "Social Innovation" and "Smart Cities".

Description – Descriptive summary of project.

Total cost – Total cost of project.

Public contribution – Three elements are reported:

  • Total commitment – total amount admitted to financing, may include more than contribution to be valued on NOP R&C, also on other funds.
  • NOP R&C admitted contribution
  • PAC admitted contribution
  • Contribution with other funds

Distribution – The following elements are reported:

  • Total distributed amount – takes into account the distributed amount considering both NOP R&C distribution and other funds if provided for
  • NOP R&C distributed amount – amount distributed to financing of project to be valued on NOP R&C
  • PAC distributed amount – amount distributed to financing of project to be valued on PAC
  • Amount distributed with other funds – amount distributed to financing of project with other funds

The distributions refer to the date of last update indicated at top.

Type of beneficiary Public commitment for beneficiary
University 2
Small business 4
Public research organisation 1
Total Beneficiaries 7

Università degli Studi di Messina

Tax File Number: 80004070837
Unique Project Code: J41H11000090005
Location of financial commitments: Non disponibile
Type: University

Presentation date 09/04/2010
Approval date 09/12/2015
Start of activity Expected date
01/01/2011
Effective date
01/09/2011
End of activity Expected date
30/07/2015
Effective date
-
Total cost 915,830.01 euro
Public contribution Total
778,455.50 euro
Eligible of NOP R&C
778,455.50 euro
Distribution Total
452,625.00 euro
Amount of NOP R&C
452,625.00 euro

Date of last distribution of NOP R&C
-

Università degli Studi di Salerno

Tax File Number: 80018670655
Unique Project Code: D41H11000190005
Location of financial commitments: Campania
Type: University

Presentation date 09/04/2010
Approval date 09/12/2015
Start of activity Expected date
01/02/2011
Effective date
01/09/2011
End of activity Expected date
30/07/2015
Effective date
-
Total cost 1,846,480.96 euro
Public contribution Total
1,569,508.82 euro
Eligible of NOP R&C
1,569,508.82 euro
Distribution Total
1,476,883.50 euro
Amount of NOP R&C
1,476,883.50 euro

Date of last distribution of NOP R&C
-

MEDIVIS SRL

Tax File Number: 11584260159
Unique Project Code: B61H11001550005
Location of financial commitments: Non disponibile
Type: Small business

Presentation date 09/04/2010
Approval date 09/12/2015
Start of activity Expected date
01/09/2011
Effective date
01/09/2011
End of activity Expected date
30/07/2015
Effective date
-
Total cost 775,589.11 euro
Public contribution Total
620,471.30 euro
Eligible of NOP R&C
620,471.30 euro
Distribution Total
446,075.15 euro
Amount of NOP R&C
446,075.15 euro

Date of last distribution of NOP R&C
-

CNR - Consiglio nazionale delle ricerche

Tax File Number: 80054330586
Unique Project Code: B61H11001540005
Location of financial commitments: Non disponibile
Type: Public research organisation

Presentation date 09/04/2010
Approval date 09/12/2015
Start of activity Expected date
01/09/2011
Effective date
01/09/2011
End of activity Expected date
30/07/2015
Effective date
-
Total cost 3,753,434.61 euro
Public contribution Total
3,190,419.41 euro
Eligible of NOP R&C
3,190,419.41 euro
Distribution Total
2,975,467.50 euro
Amount of NOP R&C
2,975,467.50 euro

Date of last distribution of NOP R&C
-

New Fa.Dem srl

Tax File Number: 06115290634
Unique Project Code: B61H11001150005
Location of financial commitments: Campania
Type: Small business

Presentation date 09/04/2010
Approval date 09/12/2015
Start of activity Expected date
01/01/2011
Effective date
01/09/2011
End of activity Expected date
30/07/2015
Effective date
-
Total cost 1,423,221.00 euro
Public contribution Total
1,061,920.80 euro
Eligible of NOP R&C
1,061,920.80 euro
Distribution Total
1,061,920.80 euro
Amount of NOP R&C
1,061,920.80 euro

Date of last distribution of NOP R&C
-

EPITECH GROUP S.p.A. - Unità operativa di Napoli

Tax File Number: 03630550287
Unique Project Code: B41H11000790005
Location of financial commitments: Non disponibile
Type: Small business

Presentation date 09/04/2010
Approval date 09/12/2015
Start of activity Expected date
01/01/2011
Effective date
01/09/2011
End of activity Expected date
30/07/2015
Effective date
-
Total cost 2,557,866.92 euro
Public contribution Total
1,569,756.92 euro
Eligible of NOP R&C
1,282,030.57 euro
Distribution Total
377,238.03 euro
Amount of NOP R&C
377,238.03 euro

Date of last distribution of NOP R&C
-

INNOVET ITALIA SRL

Tax File Number: 11929510151
Unique Project Code: B21H11000730005
Location of financial commitments: Campania, Extra convergenza
Type: Small business

Presentation date 09/04/2010
Approval date 09/12/2015
Start of activity Expected date
01/01/2011
Effective date
01/09/2011
End of activity Expected date
30/07/2015
Effective date
-
Total cost 1,478,094.93 euro
Public contribution Total
1,182,475.94 euro
Eligible of NOP R&C
889,802.34 euro
Distribution Total
477,266.94 euro
Amount of NOP R&C
477,266.94 euro

Date of last distribution of NOP R&C
-
Axis - Operational objective I - Scientific and technological fields, generators of industry transformation processes and creators of new sectors (Go to )
Action Strategic scientific and technological areas
Action line Industrial Research (Go to)
Instrument of implementation Invitation to presentation of Industrial Research projects (DD 1/Ric 18/01/10)
NSF - objective Strengthen and evaluate the whole chain of research and cooperation networks between the research system and businesses, to contribute to competitiveness and economic growth; sustain maximum distribution and use of new technologies and advanced services; heighten level of scientific and technical knowledge and skills in the production system and in institutions
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