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Information updated to: 31/08/2016

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Project

EpiSud - Programma per sviluppare metodologie per l’identificazione ed il controllo di infezioni micobatteriche animali

Code PON01_01841

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Description
Beneficiaries
Objectives

Results

Field/s	Food, Health and wellbeing
Description	The aim of this project is the discovery and characterization of biomarkers that will be used to develop innovative kits for the precocious diagnosis of pathologies with high economical impact, as tuberculosis (TB) and paratuberculosis (ParaTB) in swine, ovine, and goats. This will also lead to the improvement of our knowledge about factors influencing the diseases incidence and will also allow the implementation of effective strategies to eradicate these pathologies. For example, one could envisage the development of a genetic selection scheme based on the molecular markers for resistance to the diseases identified in the course of the project. Paratuberculosis (paraTB), whose etiological agent is /Mycobacterium avium subsp. paratuberculosis/ (MAP), is a chronic inflammation of the intestine that affects many domestic (e.g., cattle, sheep, goat) and wild species. Tuberculosis (TB), caused in animals by /Mycobacterium bovis,/ is a chronic respiratory disease characterized by the development of nodules (so-called tubercles) in the lymph-nodes of affected animals. Both pathologies are difficult to eradicate, as animals develop clinical symptoms only several years after infection and the diagnostic tools now available result really effective only during advanced stages of the diseases. For this reason, it is of paramount importance to use combined approaches to control the pathologies. These approaches should include: (i) a diagnosis based on bio-markers whose expression profile significantly changes during early phases of the infection; (ii) the selection of resistant animals based on resistance markers. The project activities will take place in Puglia and Sicilia and will be developed in 4 principal objectives. The first objective will be the collection of biological samples and epidemiological data on ParaTB and TB. This activity will allow a prior quantification of the incidence of both diseases in the Puglia and Sicilia regions, while providing the possibility to analyse in detail the risk factors that are linked to the management of the animals in selected farms. The second and third objectives will allow the identification of gene expression (such as miRNAs) and protein biomarkers suitable for the production of a diagnostic kit that will be used to precociously identify infected animals before the onset of the clinical phase, i.e., when the ELISA test normally used is not effective in the identification of the infection. The fourth objective is based on the characterization of the genetic component of the host, to identify genes and molecular markers associated with the disease resistance. This genetic information will provide the basis for the creation of a test for the identification of the most resistant animals and to set up breeding programs based on the molecular markers, along with the use of the diagnostic tools developed. Based on the know-how derived from research partners and through the development activities of industrial partners, the project will achieve products immediately available products to be used by breeders or by monitoring institutions of animal infectious diseases. The described approaches are absolutely innovative in the animal veterinary domain given that the diagnosis through the variation of genetic expression and through the proteins on easily available biological material (blood serum) is currently well established only in the human oncology field. The outcomes of the project are numerous and significant, both on cost-effective level and public health safeguard level to have genuine and guaranteed human food, mainly the dairy products.
Total cost	4,716,531.00 euro
Public contribution		Total public contribution 3,791,980.20 euro NOP R&C contribution 3,146,760.20 euro PAC contribution 0.00 euro Contribution from other funds 645,220.00 euro
Distribution	Advancement of distribution in %	Total amount distributed 2,820,507.98 euro NOP R&C distributed amount 2,626,941.98 euro PAC distributed amount 0.00 euro Amount distributed with other funds 193,566.00 euro

Legend

Field/s – Indicates the field or fields in which the project has the most relevance. A project may have more than one field. For some projects it is not assigned. The field are the following 8: "Health and wellbeing", "Food", "Energy", "Environment and Ecology", "Transport and Logistics", "Cultural goods and activities", "Social Innovation" and "Smart Cities".

Description – Descriptive summary of project.

Total cost – Total cost of project.

Public contribution – Three elements are reported:

Total commitment – total amount admitted to financing, may include more than contribution to be valued on NOP R&C, also on other funds.
NOP R&C admitted contribution
PAC admitted contribution
Contribution with other funds

Distribution – The following elements are reported:

Total distributed amount – takes into account the distributed amount considering both NOP R&C distribution and other funds if provided for
NOP R&C distributed amount – amount distributed to financing of project to be valued on NOP R&C
PAC distributed amount – amount distributed to financing of project to be valued on PAC
Amount distributed with other funds – amount distributed to financing of project with other funds

The distributions refer to the date of last update indicated at top.

Type of beneficiary

Public commitment for beneficiary

Micro business	1
Small business	2
University	1
Public research organisation	1
Total Beneficiaries	5

Cooperativa Azienda Agricola Valleverde arl

Tax File Number: 01780900831
Unique Project Code: B81C11000430005
Location of financial commitments: Sicilia

Type: Micro business

See beneficiary profile >

Presentation date	09/04/2010
Approval date	29/04/2016
Start of activity	Expected date 01/07/2011	Effective date 01/07/2011
End of activity	Expected date 31/12/2015	Effective date -
Total cost	232,350.00 euro
Public contribution	Total 185,880.00 euro	Eligible of NOP R&C 185,880.00 euro
Distribution	Total -	Amount of NOP R&C - Date of last distribution of NOP R&C -

Parco Tecnologico Padano S.r.l.

Tax File Number: 03575650969
Unique Project Code: B71C11001130005
Location of financial commitments: Sicilia, Extra convergenza

Type: Small business

See beneficiary profile >

Presentation date	09/04/2010
Approval date	29/04/2016
Start of activity	Expected date 01/07/2011	Effective date 01/07/2011
End of activity	Expected date 31/12/2015	Effective date -
Total cost	1,466,220.00 euro
Public contribution	Total 1,135,916.00 euro	Eligible of NOP R&C 490,696.00 euro
Distribution	Total 428,553.20 euro	Amount of NOP R&C 234,987.20 euro Date of last distribution of NOP R&C -

Università degli Studi di Bari Aldo Moro

Tax File Number: 80002170720
Unique Project Code: B61C11001050005
Location of financial commitments: Puglia

Type: University

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Presentation date	09/04/2010
Approval date	29/04/2016
Start of activity	Expected date 01/07/2011	Effective date 01/07/2011
End of activity	Expected date 31/12/2015	Effective date -
Total cost	1,444,817.00 euro
Public contribution	Total 1,228,094.45 euro	Eligible of NOP R&C 1,228,094.45 euro
Distribution	Total 1,228,094.45 euro	Amount of NOP R&C 1,228,094.45 euro Date of last distribution of NOP R&C -

Istituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”

Tax File Number: 00112740824
Unique Project Code: B61C11001030005
Location of financial commitments: Sicilia

Type: Public research organisation

See beneficiary profile >

Presentation date	09/04/2010
Approval date	29/04/2016
Start of activity	Expected date 01/07/2011	Effective date 01/07/2011
End of activity	Expected date 31/12/2015	Effective date -
Total cost	1,154,500.00 euro
Public contribution	Total 981,325.00 euro	Eligible of NOP R&C 981,325.00 euro
Distribution	Total 981,325.00 euro	Amount of NOP R&C 981,325.00 euro Date of last distribution of NOP R&C -

Teltec s.r.l.

Tax File Number: 02916610963
Unique Project Code: B61C11001020005
Location of financial commitments: Sicilia

Type: Small business

See beneficiary profile >

Presentation date	09/04/2010
Approval date	29/04/2016
Start of activity	Expected date 01/07/2011	Effective date 01/07/2011
End of activity	Expected date 31/12/2015	Effective date -
Total cost	418,644.00 euro
Public contribution	Total 260,764.75 euro	Eligible of NOP R&C 260,764.75 euro
Distribution	Total 182,535.33 euro	Amount of NOP R&C 182,535.33 euro Date of last distribution of NOP R&C -

Axis - Operational objective	I - Scientific and technological fields, generators of industry transformation processes and creators of new sectors (Go to )
Action	Strategic scientific and technological areas
Action line	Industrial Research (Go to)
Instrument of implementation	Invitation to presentation of Industrial Research projects (DD 1/Ric 18/01/10)
NSF - objective	Strengthen and evaluate the whole chain of research and cooperation networks between the research system and businesses, to contribute to competitiveness and economic growth; sustain maximum distribution and use of new technologies and advanced services; heighten level of scientific and technical knowledge and skills in the production system and in institutions