Profile Project

Information updated to: 31/08/2016

Project

Ricerca e sviluppo di farmaci biologici innovativi in oncologia: produzione di frammenti di anticorpi monoclonali peghilati e di miRNA ad uso terapeutico e/o diagnostico

Code PON01_01602
Field/s Health and wellbeing
Description The aim of the project is the study and application of new pegylated monoclonal antibody fragments and miRNA for therapeutic and/or diagnostic applications The main targets of the project are molecules involved in the neo-vascularisation processes such as the Endothelial Vascular Growth Factor (VEGF) and its Receptors (VEGF-R), the Endothelial Growth Factor (EGF) and its Receptors (EGF-R). The project will deal also with another marker potentially useful as a diagnostic indicator in chronic myeloid leukemia, the ABL/BCR out of frame protein (OOF) which is specifically expressed in these tumoral cells. For all these targets antibodies from phage libraries will be selected and conjugated with polyethylene glycol (with various molecular weights) to improve their therapeutic or diagnostics characteristics. It is known that small non coding RNA fragments (microRNA or miRNA) control gene expression both in normal and pathologic conditions. The project is going to study possible applications of miRNA-221/222 as potential inhibitor of the kit receptor expression as well as the use of these miRNA in kit dependent tumors (i.e. gastro intestinal stromal tumors (GIST) and some acute leukemia (AL). At the same time new synthetic ways for these miRNA will be investigated in order to block their intra- and extra-cellular degradation and to facilitate their penetration into cellular membranes or the target cells. This research project is therefore integrated in a very advanced sector of biomedical research with good perspectives for the development of proprietary innovative biological drugs in a sector, such as that of new anti-angiogenic drugs, of highly interesting in the oncology field. The project will allow the maintenance of a high scientific and technological concentration of high innovative potential characterized by an organic collaboration between industrial researchers and academic researchers.
Total cost 7,580,500.00 euro
Public contribution
Total public contribution
5,410,175.00 euro

NOP R&C contribution
4,098,225.00 euro

PAC contribution
0.00 euro

Contribution from other funds
1,311,950.00 euro
Distribution Advancement of distribution in %
Total amount distributed
4,232,693.54 euro

NOP R&C distributed amount
3,300,275.02 euro

PAC distributed amount
0.00 euro

Amount distributed with other funds
932,418.52 euro

Legend

Field/s – Indicates the field or fields in which the project has the most relevance. A project may have more than one field. For some projects it is not assigned. The field are the following 8: "Health and wellbeing", "Food", "Energy", "Environment and Ecology", "Transport and Logistics", "Cultural goods and activities", "Social Innovation" and "Smart Cities".

Description – Descriptive summary of project.

Total cost – Total cost of project.

Public contribution – Three elements are reported:

  • Total commitment – total amount admitted to financing, may include more than contribution to be valued on NOP R&C, also on other funds.
  • NOP R&C admitted contribution
  • PAC admitted contribution
  • Contribution with other funds

Distribution – The following elements are reported:

  • Total distributed amount – takes into account the distributed amount considering both NOP R&C distribution and other funds if provided for
  • NOP R&C distributed amount – amount distributed to financing of project to be valued on NOP R&C
  • PAC distributed amount – amount distributed to financing of project to be valued on PAC
  • Amount distributed with other funds – amount distributed to financing of project with other funds

The distributions refer to the date of last update indicated at top.

Type of beneficiary Public commitment for beneficiary
Micro business 1
University 1
Research Organisation 1
Total Beneficiaries 3

BIO-KER SRL

Tax File Number: 04158130965
Unique Project Code: B71C11000950005
Location of financial commitments: Non disponibile
Type: Micro business
See beneficiary profile >
Presentation date 09/04/2010
Approval date 24/06/2013
Start of activity Expected date
01/10/2011 		Effective date
01/10/2011
End of activity Expected date
31/10/2015 		Effective date
-
Total cost 4,622,500.00 euro
Public contribution Total
2,895,875.00 euro 		Eligible of NOP R&C
1,736,925.00 euro
Distribution Total
2,148,266.02 euro 		Amount of NOP R&C
1,215,847.50 euro

Date of last distribution of NOP R&C
-

UNIVERSITÀ DEGLI STUDI DI NAPOLI FEDERICO II

Tax File Number: 00876220633
Unique Project Code: B61C11001930005
Location of financial commitments: Campania
Type: University
See beneficiary profile >
Presentation date 09/04/2010
Approval date 06/07/2015
Start of activity Expected date
01/10/2011 		Effective date
01/10/2011
End of activity Expected date
31/10/2015 		Effective date
-
Total cost 2,297,400.00 euro
Public contribution Total
1,952,790.00 euro 		Eligible of NOP R&C
1,952,790.00 euro
Distribution Total
1,952,790.00 euro 		Amount of NOP R&C
1,952,790.00 euro

Date of last distribution of NOP R&C
-

IRCCS Casa Sollievo della Sofferenza

Tax File Number: 00138660717
Unique Project Code: B11C11000350005
Location of financial commitments: Puglia, Extra convergenza
Type: Research Organisation
See beneficiary profile >
Presentation date 09/04/2010
Approval date 06/07/2015
Start of activity Expected date
01/10/2011 		Effective date
01/10/2011
End of activity Expected date
31/10/2015 		Effective date
-
Total cost 660,600.00 euro
Public contribution Total
561,510.00 euro 		Eligible of NOP R&C
408,510.00 euro
Distribution Total
131,637.52 euro 		Amount of NOP R&C
131,637.52 euro

Date of last distribution of NOP R&C
-
Axis - Operational objective I - Scientific and technological fields, generators of industry transformation processes and creators of new sectors (Go to )
Action Strategic scientific and technological areas
Action line Industrial Research (Go to)
Instrument of implementation Invitation to presentation of Industrial Research projects (DD 1/Ric 18/01/10)
NSF - objective Strengthen and evaluate the whole chain of research and cooperation networks between the research system and businesses, to contribute to competitiveness and economic growth; sustain maximum distribution and use of new technologies and advanced services; heighten level of scientific and technical knowledge and skills in the production system and in institutions
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