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Information updated to: 31/08/2016

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Project

SIB: Soluzioni avanzate basate su biomateriali a matrici composite complesse per la riparazione e la rigenerazione della cartilagine articolare mediante tecniche mininvasive.

Code PON01_01287

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Description
Beneficiaries
Objectives

Results

Field/s	Health and wellbeing
Description	The project is focused on the latest trends of a rapidly growing market for the medium to long term. The world panorama of orthopedics devices see everywhere a significant growth in demand for products and techniques directed toward regenerative medicine and highly conservative surgery. This qualitative and quantitative evolution of the application is strengthened by its scientific and technical developments in the area of biomaterials. In this scenario, the aim of the project is research, development and validation of an innovative and integrated approach used to repair and regenerate articular cartilage through advanced biomaterials (hydrogels in complex matrices with specific characteristics), biopolymers and minimally invasive prosthesis. The basic objective of the system will be putting up a new system based on advanced biomaterials able to address the symptomatic treatment and therapy, to stop degeneration and possibly reverse the progress of disease of articular cartilage. The project includes 3 lines of research, divided into three main stages: LINE 1 Interpenetrating hydrogels divided into 8 stages LINE 2 Matrices and condroprotettive condroinduttive in biopolymer divided into 4 phases LINE 3 minimally invasive repair systems divided into 6 phases The research program will be held for more than 75% at the production site of Calatafimi Segesta (TP) and the remaining part at the headquarters of Villanova San Daniele (UD). The project involves the 'University of Palermo for the research and the education projects. The expected results take place on the edge of the state of the art because they allow the development of a new therapeutic approach that can provide the surgeon with a complete set of solutions for every stage of disease progression. Moreover any of these solution doesn’t exclude the others, allowing the physician to check the ongoing evolution of the disease and, if necessary ,to correct the therapeutic strategy. In particular: -For hydrogels is expected to reach an original compound with scheduled biological properties through the combination of gel created with the specific technology of Inter Penetrating hydrogels IPH, which will provide a new generation of hydrogels for biomedical applications and in particular those targeting treatment of cartilage diseases. -For biopolymers is expected to achieve effective compound to cover and regenerate articular cartilage defects by using cell-free systems with HA and serum, enriched with cells and growing factors that promote migration and differentiation of chondrogenic progenitor cells mesenchymal cells derived from bone marrow and thus the formation of cartilage repair tissue, -Systems for the repair of of large chondral and osteochondral damages (which does not allow a totally conservative approach to treat and regenerative) are expected to develop a press fit mini invasive prosthesis to be implanted after resection of small portions of highly degenerate tissue, allowing low invasiveness, and a conservative surgery. All approaches have in common the low invasiveness and a very conservative approach, respecting joint structures and surrounding tissues. This means reduced operating schedules, reduced bleeding which impact on accelerating recovery times and a reduced time-convalescence..These objectives represents not only an economic advantage for hospitals, but will also be feel as tangible innovation the patient, that will be subject to short hospitalization and will enjoy a rapid functional recovery.
Total cost	7,755,000.00 euro
Public contribution		Total public contribution 4,983,750.00 euro NOP R&C contribution 3,875,250.00 euro PAC contribution 0.00 euro Contribution from other funds 1,108,500.00 euro
Distribution	Advancement of distribution in %	Total amount distributed 2,817,836.64 euro NOP R&C distributed amount 1,907,665.30 euro PAC distributed amount 0.00 euro Amount distributed with other funds 910,171.34 euro

Legend

Field/s – Indicates the field or fields in which the project has the most relevance. A project may have more than one field. For some projects it is not assigned. The field are the following 8: "Health and wellbeing", "Food", "Energy", "Environment and Ecology", "Transport and Logistics", "Cultural goods and activities", "Social Innovation" and "Smart Cities".

Description – Descriptive summary of project.

Total cost – Total cost of project.

Public contribution – Three elements are reported:

Total commitment – total amount admitted to financing, may include more than contribution to be valued on NOP R&C, also on other funds.
NOP R&C admitted contribution
PAC admitted contribution
Contribution with other funds

Distribution – The following elements are reported:

Total distributed amount – takes into account the distributed amount considering both NOP R&C distribution and other funds if provided for
NOP R&C distributed amount – amount distributed to financing of project to be valued on NOP R&C
PAC distributed amount – amount distributed to financing of project to be valued on PAC
Amount distributed with other funds – amount distributed to financing of project with other funds

The distributions refer to the date of last update indicated at top.

Type of beneficiary

Public commitment for beneficiary

Medium business	1
University	1
Total Beneficiaries	2

LIMACORPORATE SPA

Tax File Number: 01427710304
Unique Project Code: B91C11000630005
Location of financial commitments: Sicilia, Extra convergenza

Type: Medium business

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Presentation date	09/04/2010
Approval date	13/04/2015
Start of activity	Expected date 01/06/2011	Effective date 01/06/2011
End of activity	Expected date 30/05/2015	Effective date -
Total cost	6,115,000.00 euro
Public contribution	Total 3,589,750.00 euro	Eligible of NOP R&C 2,481,250.00 euro
Distribution	Total 1,423,836.64 euro	Amount of NOP R&C 513,665.30 euro Date of last distribution of NOP R&C -

Università degli studi di Palermo

Tax File Number: 80023730825
Unique Project Code: B71C11000370005
Location of financial commitments: Sicilia

Type: University

See beneficiary profile >

Presentation date	09/04/2010
Approval date	13/04/2015
Start of activity	Expected date 01/06/2011	Effective date 01/06/2011
End of activity	Expected date 30/05/2015	Effective date -
Total cost	1,640,000.00 euro
Public contribution	Total 1,394,000.00 euro	Eligible of NOP R&C 1,394,000.00 euro
Distribution	Total 1,394,000.00 euro	Amount of NOP R&C 1,394,000.00 euro Date of last distribution of NOP R&C -

Axis - Operational objective	I - Scientific and technological fields, generators of industry transformation processes and creators of new sectors (Go to )
Action	Strategic scientific and technological areas
Action line	Industrial Research (Go to)
Instrument of implementation	Invitation to presentation of Industrial Research projects (DD 1/Ric 18/01/10)
NSF - objective	Strengthen and evaluate the whole chain of research and cooperation networks between the research system and businesses, to contribute to competitiveness and economic growth; sustain maximum distribution and use of new technologies and advanced services; heighten level of scientific and technical knowledge and skills in the production system and in institutions