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Information updated to: 31/08/2016

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Project

Studio per la realizzazione di un presidiodiagnostico per l’individuazione distrategie terapeutiche personalizzate peril diabete di tipo 2 mediante approcci digenomica e trascrittomica. (diagen-sc)

Code PON01_02460

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Description
Beneficiaries
Objectives

Results

Field/s	Health and wellbeing
Description	Diabetes mellitus represents one the leading causes of mortality in the contemporary society. It could be estimated that in the next decade, type 2 diabetes will become the most relevant chronic illness to be considered by the National and International Health Care Systems worldwide, including Italy. Although most frequently diagnosed in the adults, type 2 diabetes incidence is rapidly growing in the adolescents. Intensive programs targeted at altering lifestyle risk factors for type 2 diabetes have demonstrated substantial efficacy in reducing diabetes incidence in at-risk individuals. However, the rapid and widespread implementation of lifestyle interventions to reduce diabetes also proved to be difficult to accomplish outside of the clinical trial, further underlying the importance of improving the effectiveness and the precision of treatment and prevention through better understanding of the genetic and molecular aetiology of the disease. While genetics is often viewed as a tool to aid drug discovery, perhaps more immediately applicable is the notion that the presence of particular genetic variants will influence individual response to therapy. Thus, identifying T2D-associated genetic variation is expected to guide better drug use in the clinic. The long-term objective of the present program is the development of diagnostic tools based upon geno- and phenotypical characterization, as well as transcrptomic analysis, of T2D to differentiate patient subgroups in order to tailor therapeutic approaches to the disease. The project aims are the following: 1) To generate a data base with information on the onset and the progression of type 2 diabetes and (including the onset of diabetic complications and drug-resistance); 2) To replicate in the population of Regione Campania the association of the most common allelic variants of specific genes with the risk of developing type 2 diabetes; 3) To analyze the association of known SNPs of known genes with the presence of resistance to specific drugs in the common forms of type 2 diabetes by “pyrosequencing” procedures; 4) To identify novel molecular pathways, or novel molecura targets within known pathways in diabetic patients who developed drug-resistance, by “whole transcriptome” analysis using a new generation sequencing platform (SOLiD); 5) To generate a diagnostic tool for the identification of allelic variants of genes associated to drug-resistance in the common forms of type 2 diabetes.
Total cost	3,168,000.00 euro
Public contribution		Total public contribution 2,599,550.00 euro NOP R&C contribution 2,017,873.20 euro PAC contribution 0.00 euro Contribution from other funds 581,676.80 euro
Distribution	Advancement of distribution in %	Total amount distributed 2,138,837.50 euro NOP R&C distributed amount 1,861,750.00 euro PAC distributed amount 0.00 euro Amount distributed with other funds 277,087.50 euro

Legend

Field/s – Indicates the field or fields in which the project has the most relevance. A project may have more than one field. For some projects it is not assigned. The field are the following 8: "Health and wellbeing", "Food", "Energy", "Environment and Ecology", "Transport and Logistics", "Cultural goods and activities", "Social Innovation" and "Smart Cities".

Description – Descriptive summary of project.

Total cost – Total cost of project.

Public contribution – Three elements are reported:

Total commitment – total amount admitted to financing, may include more than contribution to be valued on NOP R&C, also on other funds.
NOP R&C admitted contribution
PAC admitted contribution
Contribution with other funds

Distribution – The following elements are reported:

Total distributed amount – takes into account the distributed amount considering both NOP R&C distribution and other funds if provided for
NOP R&C distributed amount – amount distributed to financing of project to be valued on NOP R&C
PAC distributed amount – amount distributed to financing of project to be valued on PAC
Amount distributed with other funds – amount distributed to financing of project with other funds

The distributions refer to the date of last update indicated at top.

Type of beneficiary

Public commitment for beneficiary

Small business	2
Public research organisation	1
University	1
Total Beneficiaries	4

AID Centro antidiabete Portici srl

Tax File Number: 03365501216
Unique Project Code: B71H11000790005
Location of financial commitments: Campania

Type: Small business

See beneficiary profile >

Presentation date	09/04/2010
Approval date	30/07/2015
Start of activity	Expected date 01/07/2012	Effective date 01/07/2012
End of activity	Expected date 30/09/2015	Effective date -
Total cost	155,000.00 euro
Public contribution	Total 124,000.00 euro	Eligible of NOP R&C 124,000.00 euro
Distribution	Total 111,600.00 euro	Amount of NOP R&C 111,600.00 euro Date of last distribution of NOP R&C -

CNR - Consiglio nazionale delle ricerche

Tax File Number: 80054330586
Unique Project Code: B61H11001500005
Location of financial commitments: Campania

Type: Public research organisation

See beneficiary profile >

Presentation date	09/04/2010
Approval date	30/07/2015
Start of activity	Expected date 01/07/2012	Effective date 01/07/2012
End of activity	Expected date 30/09/2015	Effective date -
Total cost	1,668,000.00 euro
Public contribution	Total 1,417,800.00 euro	Eligible of NOP R&C 1,417,800.00 euro
Distribution	Total 1,417,800.00 euro	Amount of NOP R&C 1,417,800.00 euro Date of last distribution of NOP R&C -

Diatech Pharmacogenetics srl

Tax File Number: 02483840423
Unique Project Code: B61H11001130005
Location of financial commitments: Campania, Extra convergenza

Type: Small business

See beneficiary profile >

Presentation date	09/04/2010
Approval date	30/07/2015
Start of activity	Expected date 01/07/2012	Effective date 01/07/2012
End of activity	Expected date 30/09/2015	Effective date -
Total cost	954,000.00 euro
Public contribution	Total 725,400.00 euro	Eligible of NOP R&C 143,723.20 euro
Distribution	Total 277,087.50 euro	Amount of NOP R&C - Date of last distribution of NOP R&C -

UNIVERSITÀ DEGLI STUDI DI NAPOLI FEDERICO II

Tax File Number: 00876220633
Unique Project Code: B61H11001120005
Location of financial commitments: Campania

Type: University

See beneficiary profile >

Presentation date	09/04/2010
Approval date	30/07/2015
Start of activity	Expected date 01/07/2012	Effective date 01/07/2012
End of activity	Expected date 30/09/2015	Effective date -
Total cost	391,000.00 euro
Public contribution	Total 332,350.00 euro	Eligible of NOP R&C 332,350.00 euro
Distribution	Total 332,350.00 euro	Amount of NOP R&C 332,350.00 euro Date of last distribution of NOP R&C -

Axis - Operational objective	I - Scientific and technological fields, generators of industry transformation processes and creators of new sectors (Go to )
Action	Strategic scientific and technological areas
Action line	Industrial Research (Go to)
Instrument of implementation	Invitation to presentation of Industrial Research projects (DD 1/Ric 18/01/10)
NSF - objective	Strengthen and evaluate the whole chain of research and cooperation networks between the research system and businesses, to contribute to competitiveness and economic growth; sustain maximum distribution and use of new technologies and advanced services; heighten level of scientific and technical knowledge and skills in the production system and in institutions