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Information updated to: 31/08/2016

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Project

Medicina traslazionale in Oncologia: dalla Ricerca alla Terapia

Code PON01_02418

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Description
Beneficiaries
Objectives

Results

Field/s	Health and wellbeing
Description	Translational research aims at converting the molecular knowledge generated by preclinical research into applications targeted at improving diagnosis and treatment. In Oncology, this is leading to genetic therapies based on the background of the individual patient and on the molecular profile of the individual tumor. The so called "Personalized" Therapy represents the full realization of this new approach, which is based on the assumption that the therapeutic response to a targeted drug depends on the presence and role of the target in the tumor which needs to be treated. In particular, those cancers in which the target is constitutively activated should respond to the corresponding molecular therapy. In the future, the ability to diagnose and successfully treat patients with cancer will be closely dependent on two main factors: (a) the thorough understanding of the molecular determinants of cancer and (b) the ability to translate this information into new diagnostic tests to give each patient the most suitable drug. In this scenario, the identification of new "predictive biomarkers", that is molecular characteristics capable of addressing the use of a particular drug in a specific population of patients, becomes a factor of considerable importance. To date, clinical and empirical parameters are mainly used for the design of clinical trials, with a limited number of clinical studies using molecular markers for the selection of patients to be treated. Despite obvious scientific, ethical, social and economic reasons, the early introduction of these markers in clinical trials is faltering. NMS has several clinical trials on new targeted therapies currently ongoing and is certainly interested to increase its knowledge in this area. This project proposes the ambitious goal of creating a multidisciplinary Centre able to tackle and develop the main themes of the translational research applied to cancer therapy. The project intends to trigger in Sicily the development and application of frontier technologies in genetics, genomics, bioinformatics and proteomics for the molecular characterization of various cancers, with particular regard to: (1) creating a large panel of cell lines characterized under their genetic genomic and proteomic profile, associated with the use of automated technologies for their pharmacological treatment and the identification of drug sensitivity biomarkers (2) the application of systems biology and bioinformatics approaches for large scale data analysis and integration of knowledge in mathematical models that facilitate their interpretation; (3) the creation of a bank of human tumor biopsies, prepared and preserved appropriately for molecular characterization. The overall objectives are two: 1) identifying new predictive biomarkers of sensitivity to drugs under development at NMS; (2) the development of procedures for the analysis of at least 3 biomarkers, already in use in research and/or clinical practice in Oncology. The associated training project aims to train researchers in the field of genomics, proteomics and bioinformatics, in order to develop high profile competencies in these areas. Thanks also to the localization at IOM research and contiguity with other cancer research laboratories, this project aims at creating a network based on operational protocols validated and shared between public and private centers in Sicily, but certainly open to other partnerships in Italy and abroad. The project is based on the scientific excellence and the complementary nature of the participants, including hospitals, research institutions, large enterprises and SMES, converging towards achieving objectives with significant repercussions for employment and re-launching of the local territory, and an overall strategic importance of international level.
Total cost	5,222,701.00 euro
Public contribution		Total public contribution 3,417,793.15 euro NOP R&C contribution 2,634,585.35 euro PAC contribution 0.00 euro Contribution from other funds 783,207.80 euro
Distribution	Advancement of distribution in %	Total amount distributed 1,001,805.00 euro NOP R&C distributed amount 1,001,805.00 euro PAC distributed amount 0.00 euro Amount distributed with other funds 0.00 euro

Legend

Field/s – Indicates the field or fields in which the project has the most relevance. A project may have more than one field. For some projects it is not assigned. The field are the following 8: "Health and wellbeing", "Food", "Energy", "Environment and Ecology", "Transport and Logistics", "Cultural goods and activities", "Social Innovation" and "Smart Cities".

Description – Descriptive summary of project.

Total cost – Total cost of project.

Public contribution – Three elements are reported:

Total commitment – total amount admitted to financing, may include more than contribution to be valued on NOP R&C, also on other funds.
NOP R&C admitted contribution
PAC admitted contribution
Contribution with other funds

Distribution – The following elements are reported:

Total distributed amount – takes into account the distributed amount considering both NOP R&C distribution and other funds if provided for
NOP R&C distributed amount – amount distributed to financing of project to be valued on NOP R&C
PAC distributed amount – amount distributed to financing of project to be valued on PAC
Amount distributed with other funds – amount distributed to financing of project with other funds

The distributions refer to the date of last update indicated at top.

Type of beneficiary

Public commitment for beneficiary

Non-classified	1
Large business	2
Small business	1
Total Beneficiaries	4

Fondazione Telethon

Tax File Number: 04879781005
Unique Project Code: B82C15000120005
Location of financial commitments: Campania

Type: Non-classified

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Presentation date	09/04/2010
Approval date	25/09/2015
Start of activity	Expected date 01/01/2012	Effective date 01/01/2012
End of activity	Expected date 31/10/2015	Effective date -
Total cost	364,000.00 euro
Public contribution	Total 309,400.00 euro	Eligible of NOP R&C 309,400.00 euro
Distribution	Total -	Amount of NOP R&C - Date of last distribution of NOP R&C -

Istituto Oncologico del Mediterraneo SpA

Tax File Number: 02744310877
Unique Project Code: B81C11000820005
Location of financial commitments: Sicilia

Type: Large business

See beneficiary profile >

Presentation date	09/04/2010
Approval date	25/09/2015
Start of activity	Expected date 01/01/2012	Effective date 01/01/2012
End of activity	Expected date 31/10/2015	Effective date -
Total cost	2,259,001.00 euro
Public contribution	Total 1,431,150.65 euro	Eligible of NOP R&C 1,431,150.65 euro
Distribution	Total 1,001,805.00 euro	Amount of NOP R&C 1,001,805.00 euro Date of last distribution of NOP R&C -

L.C. Laboratori Campisi Srl

Tax File Number: 01282000890
Unique Project Code: B61C11001350005
Location of financial commitments: Sicilia

Type: Small business

See beneficiary profile >

Presentation date	09/04/2010
Approval date	25/09/2015
Start of activity	Expected date 01/01/2012	Effective date 01/01/2012
End of activity	Expected date 31/10/2015	Effective date -
Total cost	502,177.00 euro
Public contribution	Total 326,415.05 euro	Eligible of NOP R&C 326,415.05 euro
Distribution	Total -	Amount of NOP R&C - Date of last distribution of NOP R&C -

Nerviano Medical Sciences Srl

Tax File Number: 04379750963
Unique Project Code: B41C11000460005
Location of financial commitments: Italia

Type: Large business

See beneficiary profile >

Presentation date	09/04/2010
Approval date	25/09/2015
Start of activity	Expected date 01/01/2012	Effective date 01/01/2012
End of activity	Expected date 31/10/2015	Effective date -
Total cost	2,097,523.00 euro
Public contribution	Total 1,350,827.45 euro	Eligible of NOP R&C 567,619.65 euro
Distribution	Total -	Amount of NOP R&C - Date of last distribution of NOP R&C -

Axis - Operational objective	I - Scientific and technological fields, generators of industry transformation processes and creators of new sectors (Go to )
Action	Strategic scientific and technological areas
Action line	Industrial Research (Go to)
Instrument of implementation	Invitation to presentation of Industrial Research projects (DD 1/Ric 18/01/10)
NSF - objective	Strengthen and evaluate the whole chain of research and cooperation networks between the research system and businesses, to contribute to competitiveness and economic growth; sustain maximum distribution and use of new technologies and advanced services; heighten level of scientific and technical knowledge and skills in the production system and in institutions