Profile Project

Information updated to: 31/08/2016

Project

SVILUPPO DI MOLECOLE CAPACI DI MODULARE VIE METABOLICHE INTRACELLULARI REDOX-SENSIBILI PER LA PREVENZIONE E LA CURA DI PATOLOGIE INFETTIVE, TUMORALI, NEURODEGENERATIVE E LORO DELIVERY MEDIANTE PIATTAFORME NANOTECNOLOGICHE

Code PON01_01802
Field/s Health and wellbeing
Description Alterations of the redox cell metabolism and related pathways play a crucial role in the pathogenesis of several diseases (infectious and inflammatory, neoplastic, neurodegenerative) The attempts to use antioxidants in therapy have not been successful so far, because of the lack of specificity, of the poor understanding of their targets and of the targeting challenges. Based on a network including pharmaceutic companies, universities and research institutes operating in convergence areas, the aim of this proposal is to identify and characterize innovative therapeutic strategies exploiting molecules acting upon specific metabolic and redox-regulated pathways and to set up nanotechnology-based delivery systems. In particular, the proposal includes industrial and pre-competitive research activities, as summarized below: - Synthesis, research and development of molecules acting upon redox-dependent pathways involved in replication of influenza A virus, Herpes simplex 1 and 2 and inflammatory response triggered by infection. The antiviral efficacy of the molecules will be validated in pre-clinical cell studies in animal models of infection; - research and development of molecules able to interfere with redox-dependent pathways, whose activation plays a critical role in neurodegenerative processes occurring during aging. The efficacy of the molecules will be validated in pre-clinical cell studies and in animal models of neurodegeneration; - synthesis of new carnitine derivatives able to interfere with specific metabolic properties of tumor cells ensuring their survival and proliferation. The efficacy of the molecules will be validated in pre-clinical studies based in models in vitro and in vivo; - research of new redox-regulated molecular targets and identification of the mechanisms involved in their modulation in various pathological contexts, focused to the synthesis of novel molecules possibly acting in the diseases investigated in the proposal; - research and development of molecules able to inhibit bacterial growth through novel molecular mechanisms; - design, set up and evaluation of the efficacy of new systems of nanotechnology-based drug delivery, with the particular focus to innovative delivery in the ophthalmic context. Molecules with validated pre-clinical efficacy will undergo phase I and II clinical trials.
Total cost 13,381,800.00 euro
Public contribution
Total public contribution
10,288,370.00 euro

NOP R&C contribution
7,877,970.00 euro

PAC contribution
0.00 euro

Contribution from other funds
2,410,400.00 euro
Distribution Advancement of distribution in %
Total amount distributed
5,989,784.52 euro

NOP R&C distributed amount
5,011,890.91 euro

PAC distributed amount
0.00 euro

Amount distributed with other funds
977,893.61 euro

Legend

Field/s – Indicates the field or fields in which the project has the most relevance. A project may have more than one field. For some projects it is not assigned. The field are the following 8: "Health and wellbeing", "Food", "Energy", "Environment and Ecology", "Transport and Logistics", "Cultural goods and activities", "Social Innovation" and "Smart Cities".

Description – Descriptive summary of project.

Total cost – Total cost of project.

Public contribution – Three elements are reported:

  • Total commitment – total amount admitted to financing, may include more than contribution to be valued on NOP R&C, also on other funds.
  • NOP R&C admitted contribution
  • PAC admitted contribution
  • Contribution with other funds

Distribution – The following elements are reported:

  • Total distributed amount – takes into account the distributed amount considering both NOP R&C distribution and other funds if provided for
  • NOP R&C distributed amount – amount distributed to financing of project to be valued on NOP R&C
  • PAC distributed amount – amount distributed to financing of project to be valued on PAC
  • Amount distributed with other funds – amount distributed to financing of project with other funds

The distributions refer to the date of last update indicated at top.

Type of beneficiary Public commitment for beneficiary
Micro business 2
Public research organisation 1
Research Organisation 1
Small business 2
Total Beneficiaries 6

Alfa Intes Industria Terapeutica Splendore SRL

Tax File Number: 04918311210
Unique Project Code: B61H11000890005
Location of financial commitments: Campania, Extra convergenza
Type: Micro business
See beneficiary profile >
Presentation date 09/04/2010
Approval date 03/11/2015
Start of activity Expected date
01/10/2011 		Effective date
01/10/2011
End of activity Expected date
31/12/2015 		Effective date
-
Total cost 4,040,000.00 euro
Public contribution Total
2,763,000.00 euro 		Eligible of NOP R&C
2,403,000.00 euro
Distribution Total
1,585,362.22 euro 		Amount of NOP R&C
1,585,362.22 euro

Date of last distribution of NOP R&C
-

CNR - Consiglio nazionale delle ricerche

Tax File Number: 80054330586
Unique Project Code: B61H11000880005
Location of financial commitments: Campania
Type: Public research organisation
See beneficiary profile >
Presentation date 09/04/2010
Approval date 03/11/2015
Start of activity Expected date
01/10/2011 		Effective date
01/10/2011
End of activity Expected date
31/12/2015 		Effective date
-
Total cost 1,613,800.00 euro
Public contribution Total
1,371,730.00 euro 		Eligible of NOP R&C
1,371,730.00 euro
Distribution Total
1,371,730.00 euro 		Amount of NOP R&C
1,371,730.00 euro

Date of last distribution of NOP R&C
-

CEINGE Biotecnologie Avanzate SCARL

Tax File Number: 04378020632
Unique Project Code: B61C11001940005
Location of financial commitments: Campania
Type: Research Organisation
See beneficiary profile >
Presentation date 09/04/2010
Approval date 03/11/2015
Start of activity Expected date
01/10/2011 		Effective date
01/10/2011
End of activity Expected date
31/12/2015 		Effective date
-
Total cost 836,000.00 euro
Public contribution Total
710,600.00 euro 		Eligible of NOP R&C
710,600.00 euro
Distribution Total
710,600.00 euro 		Amount of NOP R&C
710,600.00 euro

Date of last distribution of NOP R&C
-

CONSORZIO PITECNOBIO

Tax File Number: 04618840872
Unique Project Code: B31C11000810005
Location of financial commitments: Sicilia, Extra convergenza
Type: Micro business
See beneficiary profile >
Presentation date 09/04/2010
Approval date 03/11/2015
Start of activity Expected date
01/10/2011 		Effective date
01/10/2011
End of activity Expected date
31/12/2015 		Effective date
-
Total cost 5,598,000.00 euro
Public contribution Total
4,454,400.00 euro 		Eligible of NOP R&C
2,627,200.00 euro
Distribution Total
2,139,493.61 euro 		Amount of NOP R&C
1,161,600.00 euro

Date of last distribution of NOP R&C
-

Medestea Research & Production

Tax File Number: 08293430016
Unique Project Code: B21C11000700005
Location of financial commitments: Italia
Type: Small business
See beneficiary profile >
Presentation date 09/04/2010
Approval date 25/06/2014
Start of activity Expected date
01/10/2011 		Effective date
01/10/2011
End of activity Expected date
31/12/2015 		Effective date
-
Total cost 974,000.00 euro
Public contribution Total
748,000.00 euro 		Eligible of NOP R&C
524,800.00 euro
Distribution Total
- 		Amount of NOP R&C
-

Date of last distribution of NOP R&C
-

MEDIVIS SRL

Tax File Number: 11584260159
Unique Project Code: B11C11000560005
Location of financial commitments: Sicilia
Type: Small business
See beneficiary profile >
Presentation date 09/04/2010
Approval date 03/11/2015
Start of activity Expected date
01/10/2011 		Effective date
01/10/2011
End of activity Expected date
31/12/2015 		Effective date
-
Total cost 320,000.00 euro
Public contribution Total
240,640.00 euro 		Eligible of NOP R&C
240,640.00 euro
Distribution Total
182,598.69 euro 		Amount of NOP R&C
182,598.69 euro

Date of last distribution of NOP R&C
-
Axis - Operational objective I - Scientific and technological fields, generators of industry transformation processes and creators of new sectors (Go to )
Action Strategic scientific and technological areas
Action line Industrial Research (Go to)
Instrument of implementation Invitation to presentation of Industrial Research projects (DD 1/Ric 18/01/10)
NSF - objective Strengthen and evaluate the whole chain of research and cooperation networks between the research system and businesses, to contribute to competitiveness and economic growth; sustain maximum distribution and use of new technologies and advanced services; heighten level of scientific and technical knowledge and skills in the production system and in institutions
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