Profile Project

Information updated to: 31/08/2016

Project

“Sviluppo di modulatori delle Sirtuine come nuovo approccio terapeutico nelle patologie neurodegenerative, oncologiche e cardiovascolari (SIRT-in)”

Code PON01_01227
Field/s Health and wellbeing
Description The present proposal foresees the identification and multiparametric optimization of novel chemical entities, and specifically of inhibitors of Sirtuins (SIRT1, 2 and 3) and of selected histone-acetyltransferases (as phenocopiers of SIRT1 activation), to set the foundations for their further clinical development as novel pharmaco-therapies in the neurodegeneration, oncology and cardiovascular therapeutic areas. This interdisciplinary project is structured in 4 operational objectives. OBJECTIVE 1: IDENTIFICATION AND CHARACTERIZATION OF ACTIVE MOLECULES (HITS). •Activity 1 – Selection, virtual screening and acquisition of compound libraries. • Activity 2 – Assay development and primary screening, and profiling (chemico-physical properties) of active molecules. . • Activity 3 – Assay development and selectivity studies. OBJECTIVE 2– HIT OPTIMIZATION AND BIOLOGICAL VALIDATION • Activity 1 – Analogue design, synthesis and validation of identified actives. • Activity 2 – Structure-activity studies and evaluation of therapeutic potential in disease-based biological assays (neurodegeneration). • Activity 3 – Evaluation of therapeutic potential in disease-based biological assays (oncology and cardiovascular). • Activity 4 – Biophysical studies. OBJECTIVE 3 OPERATIVO 3 – LEAD OPTIMIZATION AND IN VIVO POC. • Activity 1 – ADMET profiling of compounds and further medicinal chemistry optimization. • Activity 2 – in vivo POC of lead molecules. Activity 3: identification of pharmacodynamic and predictive biomarkers. OBJECTIVE 4- PROJECT MANAGEMENT. Activity 1: Monitoring of Research Activities. Activity 2: Progress Reports • Activity 3 – Creation of a password protected web portal for dissemination of data amongst participants. • Activity 4 – Scientific dissemination (peer-reviewed publications and conference reports).
Total cost 8,260,629.65 euro
Public contribution
Total public contribution
6,121,647.21 euro

NOP R&C contribution
5,296,535.96 euro

PAC contribution
0.00 euro

Contribution from other funds
825,111.25 euro
Distribution Advancement of distribution in %
Total amount distributed
3,669,942.41 euro

NOP R&C distributed amount
3,162,475.61 euro

PAC distributed amount
0.00 euro

Amount distributed with other funds
507,466.80 euro

Legend

Field/s – Indicates the field or fields in which the project has the most relevance. A project may have more than one field. For some projects it is not assigned. The field are the following 8: "Health and wellbeing", "Food", "Energy", "Environment and Ecology", "Transport and Logistics", "Cultural goods and activities", "Social Innovation" and "Smart Cities".

Description – Descriptive summary of project.

Total cost – Total cost of project.

Public contribution – Three elements are reported:

  • Total commitment – total amount admitted to financing, may include more than contribution to be valued on NOP R&C, also on other funds.
  • NOP R&C admitted contribution
  • PAC admitted contribution
  • Contribution with other funds

Distribution – The following elements are reported:

  • Total distributed amount – takes into account the distributed amount considering both NOP R&C distribution and other funds if provided for
  • NOP R&C distributed amount – amount distributed to financing of project to be valued on NOP R&C
  • PAC distributed amount – amount distributed to financing of project to be valued on PAC
  • Amount distributed with other funds – amount distributed to financing of project with other funds

The distributions refer to the date of last update indicated at top.

Type of beneficiary Public commitment for beneficiary
University 1
Medium business 1
Total Beneficiaries 2

Seconda Università degli Studi di Napoli

Tax File Number: 02044190615
Unique Project Code: B61C11001960005
Location of financial commitments: Non disponibile
Type: University

Presentation date 09/04/2010
Approval date 01/10/2014
Start of activity Expected date
01/10/2011
Effective date
01/10/2011
End of activity Expected date
31/12/2015
Effective date
-
Total cost 4,473,989.65 euro
Public contribution Total
3,802,891.21 euro
Eligible of NOP R&C
3,802,891.21 euro
Distribution Total
3,147,805.00 euro
Amount of NOP R&C
3,147,805.00 euro

Date of last distribution of NOP R&C
-

Istituto Neurologico Mediterraneo – NEUROMED S.r.l.

Tax File Number: 00068310945
Unique Project Code: B11C11000250005
Location of financial commitments: Campania, Extra convergenza
Type: Medium business

Presentation date 09/04/2010
Approval date 23/12/2015
Start of activity Expected date
01/10/2011
Effective date
01/10/2011
End of activity Expected date
31/12/2015
Effective date
-
Total cost 3,786,640.00 euro
Public contribution Total
2,318,756.00 euro
Eligible of NOP R&C
1,493,644.75 euro
Distribution Total
522,137.41 euro
Amount of NOP R&C
14,670.61 euro

Date of last distribution of NOP R&C
-
Axis - Operational objective I - Scientific and technological fields, generators of industry transformation processes and creators of new sectors (Go to )
Action Strategic scientific and technological areas
Action line Industrial Research (Go to)
Instrument of implementation Invitation to presentation of Industrial Research projects (DD 1/Ric 18/01/10)
NSF - objective Strengthen and evaluate the whole chain of research and cooperation networks between the research system and businesses, to contribute to competitiveness and economic growth; sustain maximum distribution and use of new technologies and advanced services; heighten level of scientific and technical knowledge and skills in the production system and in institutions
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