Profile Project

Information updated to: 31/08/2016

Project

Modelli sperimentali biotecnologici integrati per lo sviluppo e la selezione di molecole di interesse per la salute dell'uomo

Code PON01_00937
Field/s Health and wellbeing
Description The project deals with the industrial development of molecules of interest in human health. The problems related to the research of such molecules are mainly the long times and high costs of tests on animals and humans in GMP (Good Manufacturing Practices). These experimental practices are necessary for the approval of the products, indeed a large part of tested molecules does not reach the approval in the reason of their toxicity. The high costs of production could be reduced if intermediate experimental protocols, providing information about toxicity of the new products before experimental practices on animals or humans, become available. Such protocols would decrease the useless experimental costs of potentially toxic molecules. In the present project, molecules with potential pharmacological or nutritional properties will be developed and tested using a biotechnological multidisciplinary platform that will give quantitative information on the potential toxicity. Among the developed substances there will be proteins of the HSP (Heat Shock Proteins) family, with known therapeutic effects and low molecular weight plant molecules. Representative human targets will constitute the platform. The interaction of molecules with the targets will be studied. Target selection is very important. Hexogen molecules exert their effects for more than 80% on cellular membrane systems such as transport proteins. After the intracellular absorption, they also interact with intracellular molecular systems. Toxic effects are caused by alterations of functions of molecular systems. Starting from these considerations and from the group expertise, molecular targets will be chosen, such as plasma-membrane transporters that mediates nutrients and cofactors absorption, endocellular systems like mitochondrial carriers and enzymes involved in bioenergetics. To optimize the target choice, genetic variability in human will be studied. These tests will select the target that have minor influence on individual variability. The variability, however, will be an important parameter to understand the function and to predict the contribute of individual genetics on the action of produced molecules. It is important to underline that both drug interactions with transports systems and pharmacogenomics are officially recognized by FDA (Food and Drug Administration) as biotechnological approaches to identify new biomarkers that could facilitate drugs development. To obtain a complete evaluation of the effects of these molecules, the interactions with cellular models and organs will be studied. Human cellular lines, isolated and perfused rat hearts and livers, will be used. These models are similar to human and already tested as experimental models. To predict modifications or effects before absorption, the interaction with intestinal microbiome will be evaluated. The potential toxicity will be evaluated studying parameters like IC50 that can describe the hexogen molecules effects on model systems. Moreover some known drugs will be tested as control of the experimental system. The data will be processed by existing software or by new software that will be designed through informatic expertise. As results, this project will supply new biologically active molecules, selected on the basis of their low toxicity that, after patent, will be introduced in future trials to be launched in the market. The biotechnological platform will be also used to supply consulting to other industries. This project pave the way to new occupational strategies both for industries and tertiary, to manage processes and data. The different research groups involved in the project proposal have a considerable know-how in the production of molecules of biological interest, and also in drug interactions with experimental systems proposed. This assures the fulfilling of the foreseen objective.
Total cost 4,795,484.32 euro
Public contribution
Total public contribution
3,936,624.37 euro

NOP R&C contribution
3,674,228.01 euro

PAC contribution
0.00 euro

Contribution from other funds
262,396.36 euro
Distribution Advancement of distribution in %
Total amount distributed
2,250,167.08 euro

NOP R&C distributed amount
2,125,217.08 euro

PAC distributed amount
0.00 euro

Amount distributed with other funds
124,950.00 euro

Legend

Field/s – Indicates the field or fields in which the project has the most relevance. A project may have more than one field. For some projects it is not assigned. The field are the following 8: "Health and wellbeing", "Food", "Energy", "Environment and Ecology", "Transport and Logistics", "Cultural goods and activities", "Social Innovation" and "Smart Cities".

Description – Descriptive summary of project.

Total cost – Total cost of project.

Public contribution – Three elements are reported:

  • Total commitment – total amount admitted to financing, may include more than contribution to be valued on NOP R&C, also on other funds.
  • NOP R&C admitted contribution
  • PAC admitted contribution
  • Contribution with other funds

Distribution – The following elements are reported:

  • Total distributed amount – takes into account the distributed amount considering both NOP R&C distribution and other funds if provided for
  • NOP R&C distributed amount – amount distributed to financing of project to be valued on NOP R&C
  • PAC distributed amount – amount distributed to financing of project to be valued on PAC
  • Amount distributed with other funds – amount distributed to financing of project with other funds

The distributions refer to the date of last update indicated at top.

Type of beneficiary Public commitment for beneficiary
Public research organisation 1
University 2
Large business 1
Small business 1
Research Organisation 1
Micro business 1
Total Beneficiaries 7

CNR - Consiglio nazionale delle ricerche

Tax File Number: 80054330586
Unique Project Code: B91H11000420005
Location of financial commitments: Puglia
Type: Public research organisation
See beneficiary profile >
Presentation date 09/04/2010
Approval date 28/12/2015
Start of activity Expected date
03/10/2011 		Effective date
03/10/2011
End of activity Expected date
31/12/2015 		Effective date
-
Total cost 135,200.00 euro
Public contribution Total
114,920.00 euro 		Eligible of NOP R&C
114,920.00 euro
Distribution Total
114,920.00 euro 		Amount of NOP R&C
114,920.00 euro

Date of last distribution of NOP R&C
-

Università degli Studi di Bari Aldo Moro

Tax File Number: 80002170720
Unique Project Code: B91H11000410005
Location of financial commitments: Puglia
Type: University
See beneficiary profile >
Presentation date 09/04/2010
Approval date 28/12/2015
Start of activity Expected date
03/10/2011 		Effective date
03/10/2011
End of activity Expected date
31/12/2015 		Effective date
-
Total cost 135,314.00 euro
Public contribution Total
115,016.90 euro 		Eligible of NOP R&C
115,016.90 euro
Distribution Total
115,016.90 euro 		Amount of NOP R&C
115,016.90 euro

Date of last distribution of NOP R&C
-

Metapontum Agrobios

Tax File Number: 00265840777
Unique Project Code: B81H11000590005
Location of financial commitments: Calabria
Type: Large business
See beneficiary profile >
Presentation date 09/04/2010
Approval date 28/12/2015
Start of activity Expected date
03/10/2011 		Effective date
03/10/2011
End of activity Expected date
31/12/2015 		Effective date
-
Total cost 316,351.86 euro
Public contribution Total
205,628.71 euro 		Eligible of NOP R&C
205,628.71 euro
Distribution Total
- 		Amount of NOP R&C
-

Date of last distribution of NOP R&C
-

Università della Calabria

Tax File Number: 80003950781
Unique Project Code: B51H11000260005
Location of financial commitments: Non disponibile
Type: University
See beneficiary profile >
Presentation date 09/04/2010
Approval date 14/10/2011
Start of activity Expected date
03/10/2011 		Effective date
03/10/2011
End of activity Expected date
31/12/2015 		Effective date
-
Total cost 2,487,447.00 euro
Public contribution Total
2,114,329.95 euro 		Eligible of NOP R&C
1,851,933.59 euro
Distribution Total
1,976,883.59 euro 		Amount of NOP R&C
1,851,933.59 euro

Date of last distribution of NOP R&C
-

CoreQuest Sagl

Tax File Number: 03326940784
Unique Project Code: B22C14000060006
Location of financial commitments: Calabria
Type: Small business
See beneficiary profile >
Presentation date 09/04/2010
Approval date 14/10/2011
Start of activity Expected date
03/10/2011 		Effective date
03/10/2011
End of activity Expected date
31/12/2015 		Effective date
-
Total cost 1,029,000.00 euro
Public contribution Total
823,200.00 euro 		Eligible of NOP R&C
823,200.00 euro
Distribution Total
- 		Amount of NOP R&C
-

Date of last distribution of NOP R&C
-

A.L.S.I.A.

Tax File Number: 00627370778
Unique Project Code: B12C14000070007
Location of financial commitments: Calabria
Type: Research Organisation
See beneficiary profile >
Presentation date 09/04/2010
Approval date 14/10/2011
Start of activity Expected date
03/10/2011 		Effective date
03/10/2011
End of activity Expected date
31/12/2015 		Effective date
-
Total cost 410,000.00 euro
Public contribution Total
348,500.00 euro 		Eligible of NOP R&C
348,500.00 euro
Distribution Total
- 		Amount of NOP R&C
-

Date of last distribution of NOP R&C
-

DLVSYSTEM s.r.l.

Tax File Number: 02727300788
Unique Project Code: B11H11000230005
Location of financial commitments: Non disponibile
Type: Micro business
See beneficiary profile >
Presentation date 09/04/2010
Approval date 16/02/2015
Start of activity Expected date
03/10/2011 		Effective date
03/10/2011
End of activity Expected date
31/12/2015 		Effective date
-
Total cost 282,171.46 euro
Public contribution Total
215,028.81 euro 		Eligible of NOP R&C
215,028.81 euro
Distribution Total
43,346.59 euro 		Amount of NOP R&C
43,346.59 euro

Date of last distribution of NOP R&C
-
Axis - Operational objective I - Scientific and technological fields, generators of industry transformation processes and creators of new sectors (Go to )
Action Strategic scientific and technological areas
Action line Industrial Research (Go to)
Instrument of implementation Invitation to presentation of Industrial Research projects (DD 1/Ric 18/01/10)
NSF - objective Strengthen and evaluate the whole chain of research and cooperation networks between the research system and businesses, to contribute to competitiveness and economic growth; sustain maximum distribution and use of new technologies and advanced services; heighten level of scientific and technical knowledge and skills in the production system and in institutions
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